Wednesday, July 17, 2013
Don't let them kill off the NHS
Friday, March 15, 2013
Big Pharma more of a threat than a cure
Tuesday, April 24, 2012
Big Pharma talks patent nonsense
Big Pharma never ceases to surprise but the demand from Novartis that the NHS uses one of its expensive products rather than a cheaper one really takes the biscuit.
In a bid to reduce drug costs, four NHS areas in the south of England are using a cheaper alternative to Lucentis to treat a common cause of loss of vision known as wet AMD.
Lucentis, which costs around £740 per injection, is the treatment officially recommended to the NHS in
Avastin, also made by Novartis, is not officially approved for eye conditions, but is being used when it is prescribed by a qualified opthamologist. It costs around £60 per injection.
"Avastin is internationally recognised as an effective treatment for AMD, and for example over 50% of AMD patients in the
Novartis is now going to court to claim that the hospitals are putting hospital patients at risk by using Avastin instead of Lucentis, which, coming from an industry known for all sorts of data manipulation, is really too much.
In the end, it’s about the corporation’s profits, much of which comes from supplying drugs to the NHS. The health service’s annual drugs bill is £12 billion, almost double the total cost a decade ago.
The judicial review launched by Novartis comes as the corporation renews its challenge in
This prevents generic manufacturers from producing the drug.
According to Nature magazine, Novartis is also seeking a 20-year patent on a new version of its 11-year-old anti-cancer drug Gleevec, which costs roughly $30 for one 100-milligram pill. A generic version of the drug can cost as little as $3.
Leena Menghaney, campaign coordinator of Medecins Sans Frontieres in
When India signed up to the World Trade Organisation's agreement on trade-related aspects of intellectual property rights (TRIPS) in 2005, the country won a clause that states that a drug must show a marked difference in efficacy from previous versions to be patentable. “Whereas US patent offices often grant frivolous patents on routine pharmaceutical improvements to a drug,
With final hearings in the Supreme Court scheduled for July, she warns: “If Novartis wins, many other medicines, even those that show no increased therapeutic efficacy, will be patentable in
Big Pharma – the top 20 corporations have an estimated $150 billion in resources – is more interested in protecting patents than developing new drugs against common diseases, or in persuading people to buy “lifestyle” drugs they don’t really need.
Scientists say that little new has come out of the industry over the last decade. Meanwhile, universities are starved of resources and money devoted to research. Big Pharma has an unhealthy grip on society’s collective throats that requires a strong dose of revolutionary medicine to get rid of.
Paul Feldman
Communications editor
Wednesday, December 09, 2009
Big Pharma is not good for your health
Swine flu is big business for pharmaceuticals like Roche, the manufacturer of the antiviral drug Tamiflu and the other giant corporations now producing vaccines to sell to desperate governments. Whether the products actually work is another matter and getting the trial data is nigh on impossible.
Big Pharma is effectively a secret society that owes its gigantic profits to the National Health Service in Britain and its equivalent in other countries. Take Roche and Tamiflu. Doctors say that are unable to assess how effective the anti-flu drug is because the company will not release evidence obtained from trials.
In fact, an independent review published by the British Medical Journal (BMJ) has found no evidence that Tamiflu can prevent healthy people with flu from suffering complications such as pneumonia. Although the drug may cut a day or so off the illness, it is impossible to say without access to Roche’s data. "Governments around the world have spent billions of pounds on a drug that the scientific community now finds itself unable to judge," said Dr Fiona Godlee, editor of the BMJ. Sales of Tamiflu have netted Roche sales of £1.6bn this year alone. The British government has stockpiled enough for half the population.
A second review was carried out at Birmingham University by Professor Nick Freemantle and Dr Melanie Calvert. Freemantle said he was surprised to see such a widespread use of Tamiflu and added: “But I suppose that once you've gone and bought lots of doses, then it's a bit like the situation with gun control in the US. If you have a gun in the house, it is much easier to use it. But it does not mean it's the right thing to do."
But it’s not just Roche who are cashing in. Other Big Pharma corporations are doing nicely out of producing vaccines directed at the H1N1 swine flu virus. Swiss pharmaceutical giant Novartis has opened a large-scale, cell-culture manufacturing plant in America – backed by $487 million in federal funding. The plant will be able to produce 50 million doses of seasonal flu vaccine and 150 million doses of pandemic vaccine.
One of the reasons that vaccines are back in fashion is that patents are running out on the industry’s core prescription drug business. Some $135 billion in prescription drug sales will lose patent protection in the next five years, and there's little in drug companies' pipelines to replace those sales, according to health industry analysts like Alan Sheppard of consultants IMS.
Big Pharma’s claim that it is a socially responsible industry that has to make huge profits to fund research into new drugs that are then made available to the public belongs in the realm of fantasy. For example, a study by two York University researchers last year estimates the US pharmaceutical industry spends almost twice as much on promotion as it does on research and development, contrary to the industry's claim. The study found that the industry spent 24.4% of the sales dollar on promotion, versus 13.4% for research and development, as a percentage of US domestic sales.
Big Pharma is a cash rich industry – the top 20 corporations have an estimated $150 billion in resources – that is now more interested in protecting patents than developing new drugs against common diseases, or in persuading people to buy “lifestyle” drugs they don’t really need. Scientists say that little new has come out of the industry over the last decade. Meanwhile, universities are starved of resources and money devoted to research has fallen in real terms. Big Pharma has an unhealthy grip on society’s collective throats that requires a strong dose of revolutionary medicine to loosen.
Communications editor
Monday, August 18, 2008
Milking the NHS
Professor Sir Michael Rawlins launched his tirade against drugs companies after the National Institute for Health and Clinical Excellence (Nice) was accused of “barbarism” for refusing to approve new kidney drugs for NHS use because of their cost. Rawlins said it was common knowledge that some companies charged what they thought they could get away with. “We are told we are being mean all the time, but what nobody mentions is why the drugs are so expensive,” he said. Kidney cancer drugs could be produced for about a tenth of their current cost, Rawlins claimed.
Rawlins cited three key factors in the cost of drugs. One was the fact that many older drugs were soon losing patent protection, allowing rivals to produce cheaper versions. Secondly, the price of shares was paramount. Rawlins insisted. “Pharmaceutical companies have enjoyed double-digit growth year on year and they are out to sustain that, not least because their senior management's earnings are related to the share price. It's not in their interests to take less profit, personally as well as from the point of view of the business. All these perverse incentives drive the price up.” The third factor was the cost of marketing.
This is not a new story. In 2005, the Commons health committee reported that the pharmaceutical industry “has been left to its own devices for too long” and added: “The Department of Health has for too long optimistically assumed that the interests of health and of the industry are as one. This may reflect the fact that the Department sponsors the industry as well as looking after health.”
The committee heard allegations that clinical trials could be designed to show the new drug in the best light – and sometimes failed to indicate the true effects of a medicine on health outcomes relevant to the patient. They were informed of several high-profile cases of suppression of negative clinical trial results and of selective publication strategies and ghost-writing. The committee lambasted the intensive promotion of medicines to prescribers, especially GPs. Promotion of medicines to patients and links between drug companies and patient organisations may add to this problem, said the report, which added:
“The most immediately worrying consequence of the problems described above is the unsafe use of drugs. Over-prescription of the COX-2 inhibitors, Vioxx and Celebrex, has been linked to thousands of deaths and many more cases of heart failure. These cases illustrate a series of failures. Manufacturers are known to have suppressed certain trials for these drugs in the US and may have done the same in the UK. In addition, there were inadequacies in the licensing and post-marketing surveillance procedures and excessive promotion of the drugs to doctors.”
The NHS drugs bill has doubled under New Labour to over £11 billion a year, 80% of which goes on prescribed medicines. The real question is, if 1.3 million people can work in the not-for-profit NHS, with the majority of basic research done in publicly-funded universities, why can’t drugs be produced in the same way? The answer is that the market state acts as a guarantor for the drugs companies instead of the needs of the sick and is a barrier to the comprehensive socialisation of health care.
Paul Feldman
Communications editor
Tuesday, March 25, 2008
The hidden unholy alliance
Cardinals and bishops throughout the land used Easter to launch ferocious attacks on the government for refusing – so far - to allow a “free vote” in the Commons. Cardinal O'Brien, Scotland's most senior Catholic cleric denounced what he called "Frankenstein" experiments and called the Bill’s proposals a "monstrous attack on human rights, human dignity and human life". The Church of England joined the fray in the form of Tom Wright, the Bishop of Durham. He saw fit to denounce the government for “pushing through, hard and fast, legislation that comes from a militantly atheist and secularist lobby”.
Cardinal Cormac Murphy-O'Connor, the Archbishop of Westminster, has called for Labour MPs to be granted a free vote, saying: "I think Catholics in politics have got to act according to their Catholic convictions, so have other Christians, so have other politicians.” Three Catholic cabinet ministers are taking their cue from the Pope’s man in Britain - Welsh Secretary Paul Murphy, Transport Secretary Ruth Kelly (a member of the highly secret, far-right Opus Dei sect) and Defence Secretary Des Brown – and are threatening to leave the government.
They oppose the Bill because it allows the use of cloned embryos in the very early moments after fertilisation, which they claim is a form of murder. The Catholic Church’s opposes abortion on similar grounds. In fact, the use of stem-cell therapies, which is what the tiny balls of cells (which in no-way can be called human beings) are used for, has already been proved beneficial in treating Parkinson’s disease. The Catholic Church and other opponents of scientific knowledge want to cash in, as always, on people’s fears and ignorance of the hidden processes by which a human being arises from just those clumps of cells.
There is an entirely justified fear and distrust of another unholy and hidden alliance – that between politicians of all parties and the global corporations whose interests dominate scientific and medical research of all kinds. Brown’s main concern is that biotech corporations will be left behind by their competitors if the Bill doesn’t go through. How they steal an advantage is another thing. Only recently GlaxoSmithKline was forced to admit that it had covered up the fatal effects of Prozac on young people by refusing to place internal research in the public domain.
The secrecy surrounding patents of new medicines, the use of wide swathes of the population as guinea pigs for new drugs, the premature prescribing of new products due to pressures from corporations on the medical profession – in short, the wholesale entry of market forces into the National Health Service have all contributed to fears of unchecked experimentation.
In our book, A World to Win, we document the way in which the Biotechnology and Biological Sciences Research Council is dominated by commercial interests, in particular companies like GlaxoSmithKline, Astra-Zenica, Unilever and United Biscuits.
At present, the choice is between leaving the questions of scientific research to a toothless parliament in hock to corporate interests, who will secretly experiment on people, or endure new forms of moral intolerance and anti-science, parading under the banner of “freedom of conscience”. There has to be another way. The row over this Bill shows the urgent need for a science that is financed and controlled with the interests of society as a whole at the centre of research rather than the balance sheets of Big Pharma.
Corinna Lotz
AWTW secretary
Thursday, July 12, 2007
London NHS review smokescreen
But deep in the report, and destined to disappear, are links with the Mayor’s Health Inequalities Strategy and acknowledgement of the long-forgotten Wanless reviews carried out in 2002, 2003, and 2004 which concluded that the "fully engaged scenario’" was the cheapest option and delivered the best health outcomes. In this scenario, the level of public engagement in relation to health is high, life expectancy goes beyond current forecasts, health status improves dramatically, use of resources is more efficient and the health service is responsive with high rates of technology uptake.
Professor Sir Aru Darzi, author of the new report, commissioned by London’s Strategic Health Authority, is a high achieving, and internationally-respected surgeon soon to become a life peer. Having completed his report, Professor Darzi has been drawn into Gordon Brown’s government as a junior minister and is charged with yet another review of the NHS as a whole. And the image of high-tech surgical incisiveness is being used to replace the messy business of democratic participation.
Brown’s enthusiastic adoption of Professor Darzi’s clinically-led, needs-based approach is a cynical smokescreen designed to bring the influential doctors onboard. The NHS infrastructure consists of an ageing stock of buildings being replaced by privately-financed millstones of debt. But the debt remains, and Brown’s commitment to the voracious needs of the City of London will ensure that the doctor’s enthusiasm for science is subordinated to it. Whilst Darzi is careful to say that the PFI-funded old-style hospitals can be reused in his revamped integrated service, he also offers up surplus land as a means to finance development. Estate agents and speculators will be rubbing their hands in glee.
Darzi’s claim to have sought the views of Londoners can hardly be described as comprehensive, nor did its methods match up to the Wanless "fully-engaged scenario" it references. Ipsos MORI conducted just 20 minute of telephone interviews amongst 7,036 London residents between 22nd September and 27th November 2006. Londoners’ health and social needs must be based on a fully-participative democratic process, involving residents, managers, doctors, paramedics and nurses, whose members in England in an historic move are about to launch a formal ballot on industrial action over the government’s below inflation pay offer.
Gerry Gold, economics editor
Friday, March 16, 2007
Bird flu: a bonanza for Big Chicken
In Indonesia, Russia, India and Egypt, as well as in the UK, governments and the international agencies are rushing to the industry's defence, turning the bird flu crisis into an opportunity for the larger corporations to consolidate their control. GRAIN’s report says that the company that probably first brought bird flu to Vietnam is ready to take advantage of the latest crisis. "Charoen Pokphand (CP) will succeed in turning a crisis into an opportunity of development," says Sooksunt Jiumjaiswanglerg, president of CP Vietnam Livestock. The giant Thai-based transnational corporation, which supplies fast-food chains in Asia like KFC, controls around 80% of Vietnam's industrial chicken production and anticipates its growth in the country to soar by 30% per year. "Yet in a nation where an estimated 80% of the country's poultry production was at least until recently in the hands of small scale producers and over 70% of Vietnamese households keep poultry, it is no wonder that many independent poultry raisers are simply taking their chances and going underground," GRAIN reports.
The conflict over avian flu is widening to bring some countries into confrontation with the pharmaceutical giants. Indonesia, following China, has cut the supply of local H5N1 (bird flu) virus samples to the World Health Organisation, in an attempt to prevent big pharmaceutical manufacturers accessing the information to produce proprietary drugs. As GRAIN says, the whole power imbalance cemented into this system is grotesque. Poor countries supply "raw materials", for free, to a global pharmaceutical industry that concentrates market power and reaps huge profits through monopoly privileges called patents. Meanwhile, it is the poor countries that are facing the biggest public health problems. Indonesia has been calling for the WHO and others to help them develop the capacity to produce vaccines for themselves. But pharmaceutical corporations like Syngenta, Novartis and Pfizer are fighting ferociously in India, Thailand and the Philippines to prevent compulsory licensing and generic manufacturing. Any vaccine against a bird flu pandemic and the technology to produce it, should be shared and made available for free. The patent system serves little purpose in the health field except to enrich drug companies and their shareholders and is a barrier to tackling threatened pandemics like Avian flu, which themselves have their origin in industrialised agriculture.
Gerry Gold, economics editor